Silencing of YAP attenuates pericyte‐myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11809
Abstract: Age‐related macular degeneration (AMD) is the main reason of irreversible vision loss in the elderly. The subretinal fibrosis subsequent to choroidal neovascularization (CNV) is an important feature in the late stage of wet AMD and… read more here.
Keywords: pericyte myofibroblast; subretinal fibrosis; cnv; choroidal neovascularization ... See more keywords
Rho-kinase inhibition reduces subretinal fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02709-0
Abstract: Subretinal fibrosis, a consequence of choroidal neovascularization (CNV) in age-related macular degeneration (AMD), leads to irreversible vision loss due to excessive accumulation of extracellular matrix (ECM) proteins and fibrotic scarring. Anti-VEGF therapy can reverse neovascularization,… read more here.
Keywords: fibrosis; kinase inhibition; reduces subretinal; rho kinase ... See more keywords
METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad005
Abstract: Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration (nAMD). Myofibroblasts originated from retinal pigment epithelial (RPE) cells through epithelial-mesenchymal transition (EMT) contribute to the fibrosis… read more here.
Keywords: m6a modification; subretinal fibrosis; rpe cells; mettl3 ... See more keywords
Deficiency of 2-Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial-to-Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2025 at "Aging cell"
DOI: 10.1111/acel.70271
Abstract: Subretinal fibrosis significantly contributes to vision loss in neovascular age‐related macular degeneration (nAMD). Epithelial‐to‐mesenchymal transition (EMT) in RPE cells is a key early step in subretinal fibrosis. While mitochondrial dysfunction in RPE is involved, the… read more here.
Keywords: related macular; macular degeneration; fibrosis; neovascular age ... See more keywords
Subretinal fibrosis occurrence according to macular neovascularisation subtypes in neovascular age‐related macular degeneration
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.16759
Abstract: To assess subretinal fibrosis (SF) occurrence in neovascular age‐related macular degeneration (nAMD), according to macular neovascularisation (MNV) subtypes. read more here.
Keywords: fibrosis occurrence; related macular; macular degeneration; neovascular age ... See more keywords
Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice
Sign Up to like & getrecommendations! Published in 2024 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adk3868
Abstract: Anti–vascular endothelial growth factor therapy has had a substantial impact on the treatment of choroidal neovascularization (CNV) in patients with neovascular age-related macular degeneration (nAMD), the leading cause of vision loss in older adults. Despite… read more here.
Keywords: mesenchymal transition; receptor; fibrosis; subretinal fibrosis ... See more keywords
Prevalence, multimodal imaging and genotype-phenotype assessment of trauma related subretinal fibrosis in stargardt disease
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Ophthalmology"
DOI: 10.1177/11206721221093986
Abstract: Background and Objectives Stargardt disease produces lipofuscin accumulation predisposing to subretinal fibrosis (SRFib) after ocular trauma. Noninvasive imaging techniques allow in vivo assessment. The purpose of this study is to determine the prevalence of SRFib… read more here.
Keywords: stargardt disease; subretinal fibrosis; trauma; multimodal imaging ... See more keywords
Inhibitory effect on subretinal fibrosis by anti-placental growth factor treatment in a laser-induced choroidal neovascularization model in mice.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2022.02.01
Abstract: AIM To investigate whether anti-placental growth factor (PGF) can inhibit subretinal fibrosis and whether this effect is mediated by the inhibitory effect of PGF on epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells. METHODS… read more here.
Keywords: anti; pgf; rpe cells; effect ... See more keywords