Metabolic Profiling Identifies De Novo Nucleotide Synthesis As a Potential Metabolic Vulnerability for Targeted Therapy Against Mantle Cell Lymphoma
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DOI: 10.1182/blood-2018-99-112192
Abstract: Introduction: Cancer cells exhibit dramatic alterations in cellular metabolism, such as enhanced de novo nucleotide synthesis, to support cell growth, proliferation and survival. The abundance of the nucleotide pool as well as the level and… read more here.
Keywords: subset mcl; novo nucleotide; nucleotide synthesis; cell ... See more keywords