Arginine 58 is indispensable for proper function of the Francisella tularensis subsp. holarctica FSC200 HU protein, and its substitution alters virulence and mediates immunity against wild-type strain
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DOI: 10.1080/21505594.2022.2132729
Abstract: ABSTRACT HU protein, a member of the nucleoid-associated group of proteins, is an important transcription factor in bacteria, including in the dangerous human pathogen Francisella tularensis. Generally, HU protein acts as a DNA sequence non-specific… read more here.
Keywords: tularensis subsp; fsc200; tularensis; subsp holarctica ... See more keywords
Differential Substrate Usage and Metabolic Fluxes in Francisella tularensis Subspecies holarctica and Francisella novicida
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DOI: 10.3389/fcimb.2017.00275
Abstract: Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease, tularemia. Whereas F. tularensis subsp. holarctica is highly pathogenic for humans, F. novicida is almost avirulent for humans, but virulent for mice.… read more here.
Keywords: subsp holarctica; tularensis subsp; tularensis; francisella ... See more keywords
Development and Properties of Francisella tularensis Subsp. holarctica 15 NIIEG Vaccine Strain without the recD Gene
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DOI: 10.3390/vaccines10010108
Abstract: The genomic analysis of all subspecies F. tularensis, as found in Gen Bank NCBI, reveals the presence of genes encoding proteins like to the multifunctional RecBCD enzyme complex in E. coli and other bacteria. To… read more here.
Keywords: tularensis subsp; recd gene; strain; tularensis ... See more keywords