Imaging of nigrosome 1 in substantia nigra at 3T using multiecho susceptibility map‐weighted imaging (SMWI)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25553
Abstract: To enhance the visibility of nigrosome 1 in substantia nigra, which has recently been suggested as an imaging biomarker for Parkinson's disease (PD) at 3T magnetic resonance imaging (MRI). read more here.
Keywords: nigrosome substantia; substantia nigra; nigra using; imaging nigrosome ... See more keywords
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24363
Abstract: Adeno‐associated virus (AAV) vector‐mediated delivery of human α‐synuclein (α‐syn) gene in rat substantia nigra (SN) results in increased expression of α‐syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. Therefore, this… read more here.
Keywords: aav; substantia nigra; expression; downregulation ... See more keywords
Electrical activation of the pedunculopontine tegmental nucleus modulates the neuronal activities of the subthalamic nucleus and the substantia nigra pars reticulata in anesthetized rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25117
Abstract: The subthalamic nucleus (STN), substantia nigra pars reticulata (SNr), and pedunculopontine tegmental nucleus (PPTg) are reciprocally connected brain regions that play significant roles in the motor control. However, the electrophysiological relationship among the STN, SNr,… read more here.
Keywords: subthalamic nucleus; substantia nigra; stn snr; pptg ... See more keywords
Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27318
Abstract: Background: Susceptibility MRI may capture Parkinson's disease‐related pathology. This study delineated longitudinal changes in different substantia nigra regions. read more here.
Keywords: susceptibility mri; substantia nigra; parkinson;
Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28988
Abstract: Neurodegeneration in the substantia nigra pars compacta (SNc) in parkinsonian syndromes may affect the nigral territories differently. read more here.
Keywords: nigra atypical; substantia nigra; regional selectivity; selectivity neuromelanin ... See more keywords
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29311
Abstract: Susceptibility magnetic resonance imaging (MRI) is sensitive to iron‐related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron deposition in the SNc is associated… read more here.
Keywords: magnetic resonance; pars compacta; nigra pars; resonance imaging ... See more keywords
Neurometabolic profiles of the substantia nigra and striatum of MPTP‐intoxicated common marmosets: An in vivo proton MRS study at 9.4 T
Sign Up to like & getrecommendations! Published in 2017 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3686
Abstract: Given the strong coupling between the substantia nigra (SN) and striatum (STR) in the early stage of Parkinson's disease (PD), yet only a few studies reported to date that have simultaneously investigated the neurochemistry of… read more here.
Keywords: mptp; group; mptp weeks; mrs ... See more keywords
Automated volumetric determination of high R2* regions in substantia nigra: A feasibility study of quantifying substantia nigra atrophy in progressive supranuclear palsy
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4795
Abstract: The establishment of an unbiased protocol for the automated volumetric measurement of iron‐rich regions in the substantia nigra (SN) is clinically important for diagnosing neurodegenerative diseases exhibiting midbrain atrophy, such as progressive supranuclear palsy (PSP).… read more here.
Keywords: atrophy progressive; substantia nigra; automated volumetric; regions substantia ... See more keywords
The expression change of glial fibrillary acidic protein and tyrosine hydroxylase in substantia nigra of the Wistar rats exposed to chlorpyrifos: a novel environmental risk factor for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Brain Research"
DOI: 10.1007/s00221-020-05868-x
Abstract: Chlorpyrifos (CPF) is one of the most abundant and widely used pesticides in the world. CPF has detrimental effects on brain tissue, so it is possible to generate some neurodegenerative diseases. The aim of this… read more here.
Keywords: group; substantia nigra; expression; parkinson disease ... See more keywords
[18F]AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1507-y
Abstract: This study investigated binding of [18F]AV-1451 to neuromelanin in the substantia nigra of patients with Parkinson’s disease (PD) and progressive supranuclear palsy (PSP). [18F]AV-1451 is a positron emission tomography radiotracer designed to bind pathological tau.… read more here.
Keywords: psp; neuromelanin substantia; binding; substantia nigra ... See more keywords
Opposing collicular influences on the parafascicular (Pf) and posteromedial (POm) thalamic nuclei: relationship to POm-induced inhibition in the substantia nigra pars reticulata (SNR)
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1534-8
Abstract: The superior colliculus activates the zona incerta (ZI), which sends GABAergic projections to the posteromedial (POm) thalamic nucleus. Consistent with this circuit, we previously showed that stimulation of the superior colliculus activates ZI and causes… read more here.
Keywords: thalamic nuclei; pom; stimulation; pom thalamic ... See more keywords