Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model.
Sign Up to like & getrecommendations! Published in 2025 at "Brain and behavior"
DOI: 10.1002/brb3.71124
Abstract: St. John's wort (Hypericum perforatum) has been used for centuries as a medicinal plant to remedy external disorders such as burns and wounds, as well as internal disorders such as nerve pain, anxiety, and depression.… read more here.
Keywords: cells parkinson; stem; stem cells; john wort ... See more keywords
Imaging of nigrosome 1 in substantia nigra at 3T using multiecho susceptibility map‐weighted imaging (SMWI)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25553
Abstract: To enhance the visibility of nigrosome 1 in substantia nigra, which has recently been suggested as an imaging biomarker for Parkinson's disease (PD) at 3T magnetic resonance imaging (MRI). read more here.
Keywords: nigrosome substantia; substantia nigra; nigra using; imaging nigrosome ... See more keywords
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24363
Abstract: Adeno‐associated virus (AAV) vector‐mediated delivery of human α‐synuclein (α‐syn) gene in rat substantia nigra (SN) results in increased expression of α‐syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. Therefore, this… read more here.
Keywords: aav; substantia nigra; expression; downregulation ... See more keywords
Electrical activation of the pedunculopontine tegmental nucleus modulates the neuronal activities of the subthalamic nucleus and the substantia nigra pars reticulata in anesthetized rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25117
Abstract: The subthalamic nucleus (STN), substantia nigra pars reticulata (SNr), and pedunculopontine tegmental nucleus (PPTg) are reciprocally connected brain regions that play significant roles in the motor control. However, the electrophysiological relationship among the STN, SNr,… read more here.
Keywords: subthalamic nucleus; substantia nigra; stn snr; pptg ... See more keywords
Substantia Nigra as Brainstem Signature in Pediatric-Onset Huntington's Disease: The RAREST-JHD Study.
Sign Up to like & getrecommendations! Published in 2025 at "Movement disorders clinical practice"
DOI: 10.1002/mdc3.70382
Abstract: BACKGROUND Pediatric-onset Huntington's disease (POHD) is usually associated with signs and symptoms of parkinsonism and dystonia predominating on chorea, which is typical of adult-onset HD (AOHD). Brain changes responsible of such an atypical POHD phenotype… read more here.
Keywords: pediatric onset; huntington disease; onset huntington; huntington ... See more keywords
Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27318
Abstract: Background: Susceptibility MRI may capture Parkinson's disease‐related pathology. This study delineated longitudinal changes in different substantia nigra regions. read more here.
Keywords: susceptibility mri; substantia nigra; parkinson;
Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism
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DOI: 10.1002/mds.28988
Abstract: Neurodegeneration in the substantia nigra pars compacta (SNc) in parkinsonian syndromes may affect the nigral territories differently. read more here.
Keywords: nigra atypical; substantia nigra; regional selectivity; selectivity neuromelanin ... See more keywords
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29311
Abstract: Susceptibility magnetic resonance imaging (MRI) is sensitive to iron‐related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron deposition in the SNc is associated… read more here.
Keywords: magnetic resonance; pars compacta; nigra pars; resonance imaging ... See more keywords
Neurometabolic profiles of the substantia nigra and striatum of MPTP‐intoxicated common marmosets: An in vivo proton MRS study at 9.4 T
Sign Up to like & getrecommendations! Published in 2017 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3686
Abstract: Given the strong coupling between the substantia nigra (SN) and striatum (STR) in the early stage of Parkinson's disease (PD), yet only a few studies reported to date that have simultaneously investigated the neurochemistry of… read more here.
Keywords: mptp; group; mptp weeks; mrs ... See more keywords
Automated volumetric determination of high R2* regions in substantia nigra: A feasibility study of quantifying substantia nigra atrophy in progressive supranuclear palsy
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4795
Abstract: The establishment of an unbiased protocol for the automated volumetric measurement of iron‐rich regions in the substantia nigra (SN) is clinically important for diagnosing neurodegenerative diseases exhibiting midbrain atrophy, such as progressive supranuclear palsy (PSP).… read more here.
Keywords: atrophy progressive; substantia nigra; automated volumetric; regions substantia ... See more keywords
The expression change of glial fibrillary acidic protein and tyrosine hydroxylase in substantia nigra of the Wistar rats exposed to chlorpyrifos: a novel environmental risk factor for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Brain Research"
DOI: 10.1007/s00221-020-05868-x
Abstract: Chlorpyrifos (CPF) is one of the most abundant and widely used pesticides in the world. CPF has detrimental effects on brain tissue, so it is possible to generate some neurodegenerative diseases. The aim of this… read more here.
Keywords: group; substantia nigra; expression; parkinson disease ... See more keywords