Discovery of N-Substituted Acetamide Derivatives as Promising P2Y14R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay.
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DOI: 10.1021/acs.jmedchem.4c00555
Abstract: P2Y14 receptor (P2Y14R) is activated by uridine 5'-diphosphate-glucose, which is involved in many human inflammatory diseases. Based on the molecular docking analysis of currently reported P2Y14R antagonists and the crystallographic overlap study between the reported… read more here.
Keywords: substituted acetamide; p2y14r; acetamide derivatives; derivatives promising ... See more keywords