A Cyclohexyl-Fused Spirobiindane-derived Phosphine-catalyzed Synthesis of Tricyclic γ-Lactams and Kinetic Resolution of γ-Substituted Allenoates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b07418
Abstract: A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted alleno-ates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams… read more here.
Keywords: cyclohexyl fused; fused spirobiindane; tricyclic lactams; kinetic resolution ... See more keywords
Phosphine-catalyzed divergent domino processes between γ-substituted allenoates and carbonyl-activated alkenes
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06364b
Abstract: Highly enantioselective and chemodivergent domino reactions between γ-substituted allenoates and activated alkenes have been developed. In the presence of NUSIOC-Phos, triketone enone substrates smoothly reacted with γ-substituted allenoates to form bicyclic furofurans in good yields… read more here.
Keywords: divergent domino; substituted allenoates; catalyzed divergent; activated alkenes ... See more keywords