Hit discovery of novel 2‐phenyl‐substituted 4‐amino–6,7‐dihydro‐5H‐cyclopenta[d]pyrimidines as potential anti‐glioblastoma therapeutics: Design, synthesis, biological evaluation, and computational screening
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22046
Abstract: Glioblastoma multiforme (GBM) is a highly‐aggressive, dreadful disease with poor prognosis and disappointing clinical success. There is an unmet medical need of molecularly‐targeted therapeutics for GBM treatment. In the present work, a series of novel… read more here.
Keywords: glioblastoma; dihydro cyclopenta; novel phenyl; amino dihydro ... See more keywords
A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2016.08.005
Abstract: A new ureido-substituted amino acid, conopsamide A (1), has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configuration was assigned… read more here.
Keywords: amino acid; new ureido; substituted amino; gymnadenia conopsea ... See more keywords
Electrochemical behaviour of amino substituted β-amino α,β-unsaturated ketones: A computational chemistry and experimental study
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2018.11.144
Abstract: Abstract The synthesis, identification and electrochemical properties are reported here, for a series of five novel and seven known amino substituted β-amino α,β-unsaturated ketones (bidentate N,O-ligands) of the type CH3COCHC(NHR)CH3, where R = H, Ph, CH2Ph, CH(CH3)2,… read more here.
Keywords: substituted amino; amino; amino substituted; chemistry ... See more keywords
Trading N and O. Part 4: Asymmetric synthesis of syn-β-substituted-α-amino acids
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.071
Abstract: Abstract A total of nine enantiopure syn-β-substituted-α-amino acids have been synthesised, comprising both syn-β-hydroxy-α-amino acids and syn-β-fluoro-α-amino acids. The key step in the synthetic strategy towards these syn-β-substituted-α-amino acids involves a stereospecific rearrangement, which proceeds… read more here.
Keywords: syn substituted; amino acids; substituted amino; hydroxy ... See more keywords
Electrocarboxylation of N-Acylimines with Carbon Dioxide: Access to Substituted α-Amino Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01267
Abstract: Direct electrocarboxylation of various N-acylimines with atmospheric CO2 is achieved in an undivided cell under mild conditions, affording substituted α-amino acids in yields of 62-95%. This reaction is conducted with high efficiency using triethanolamine as… read more here.
Keywords: amino acids; carbon dioxide; electrocarboxylation acylimines; substituted amino ... See more keywords
Synthesis of N-Substituted 3-Amino-2-pyridones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02189
Abstract: Pyridones are versatile building blocks in organic synthesis and a privileged motif in drug discovery. However, N-substituted 2-pyridones bearing an α-tertiary carbon, cyclopropyl, or heterocycle off of the pyridone nitrogen atom remain challenging to prepare.… read more here.
Keywords: synthesis substituted; chemistry; substituted amino; synthesis ... See more keywords
Nickel-Catalyzed Formation of α-Substituted γ-Amino Ketones via Alkene Carboacylation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03413
Abstract: Herein, we report Ni-catalyzed intramolecular carboacylation of imides containing a tethered alkene and tetraarylborate nucleophiles. Using a nickel-phosphine catalyst system, α-substituted, γ-amino ketones are generated in up to 92% yield with site selectivity. Deprotection and… read more here.
Keywords: catalyzed formation; nickel catalyzed; amino ketones; substituted amino ... See more keywords
Divergent Synthesis of Substituted Amino-1,2,4-triazole Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Synthesis"
DOI: 10.1055/a-1477-4630
Abstract: A divergent efficient assembly of disubstituted 1,2,4-triazoles was established by cyclization of readily accessible N′-nitro-2-hydrocarbylidene-hydrazinecarboximidamides with moderate to excellent yields under mild reaction conditions. This divergent synthetic strategy was achieved simply by varying the reaction… read more here.
Keywords: amino triazole; substituted amino; synthesis substituted; synthesis ... See more keywords
Synthesis of N-Substituted 2-Amino-3,4-diiodofurans from Allenes via NIS-Mediated Intramolecular Electrophilic Iodocyclization
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1588792
Abstract: A facile and efficient method for the syntheses of N-substituted 2-amino-3,4-diiodofurans from various readily available allenic amides has been developed. The reaction was postulated to proceed via an NIS-mediated electrophilic iodocyclization pathway. read more here.
Keywords: substituted amino; nis mediated; amino diiodofurans; electrophilic iodocyclization ... See more keywords
Synthesis and structure of some substituted 2-amino-4-aryl-7-propargyloxy-4H-chromene-3-carbonitriles
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1543779
Abstract: Abstract A series of 2-amino-7-hydroxy-4H-chromene-3-carbonitriles 4a-l were synthesized through three-component reaction using sodium carbonate as a catalyst. The reaction was carried out in 96% ethanol-water medium (1:20 ratio in volume). Propargyl ether compounds 5a-l of… read more here.
Keywords: chromene; substituted amino; structure substituted; synthesis structure ... See more keywords
Synthesis of Novel 2- and 8-Substituted 4-Amino-7-chloroquinolines and their N-Alkylated Coupling Products
Sign Up to like & getrecommendations! Published in 2023 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2023-0005
Abstract: The synthesis of a series of 2- and 8-substituted 4-amino-7-chloroquinolines is presented. The chloro in the 7-position can be effectively substituted using amino alcohols to yield novel analogues of the antimalarial (hydroxy)chloroquine. Both short chain… read more here.
Keywords: chloroquinolines alkylated; substituted amino; novel substituted; amino chloroquinolines ... See more keywords