Selective Fluorination of 4-Substituted 2-Aminopyridines and Pyridin-2(1 H)-ones in Aqueous Solution.
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DOI: 10.1021/acs.orglett.8b02003
Abstract: Fluorination of 2-aminopyridines and pyridin-2(1 H)-ones in the presence of Selectfluor, water, and chloroform under mild conditions has been realized. This method gives fluorinated pyridines in good to high yields with high regioselectivities. The electron-deficient… read more here.
Keywords: selective fluorination; aminopyridines pyridin; pyridin ones; fluorination ... See more keywords