Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I
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DOI: 10.1055/s-0039-1690772
Abstract: A library of novel 2-substituted derivatives of the antibiotic natural product pentenomycin I is presented. The new collection of analogues is divided in two main classes, 2-alkynyl- and 2-aryl- derivatives, which are accessed by the… read more here.
Keywords: novel; evaluation novel; biological evaluation; novel substituted ... See more keywords
α,ω-Diacyl-Substituted Analogues of Natural and Unnatural Polyamines: Identification of Potent Bactericides That Selectively Target Bacterial Membranes
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DOI: 10.3390/ijms24065882
Abstract: In this study, α-ω-disubstituted polyamines exhibit a range of potentially useful biological activities, including antimicrobial and antibiotic potentiation properties. We have prepared an expanded set of diarylbis(thioureido)polyamines that vary in central polyamine core length, identifying… read more here.
Keywords: analogues natural; bacterial membranes; diacyl substituted; substituted analogues ... See more keywords
3-Amino-Substituted Analogues of Fusidic Acid as Membrane-Active Antibacterial Compounds
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DOI: 10.3390/membranes13030309
Abstract: Fusidic acid (FA) is an antibiotic with high activity against Staphylococcus aureus; it has been used in clinical practice since the 1960s. However, the narrow antimicrobial spectrum of FA limits its application in the treatment… read more here.
Keywords: membrane; spermine; effect; activity ... See more keywords