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Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00813
Abstract: Leishmaniasis, a disease caused by protozoa of the Leishmania species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic, expensive, difficult to administer, and subject to drug resistance. We report a…
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Keywords:
heteroarylquinolines potential;
substituted aryl;
potential antileishmanial;
aryl heteroarylquinolines ... See more keywords
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Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05057
Abstract: Enolizations of highly substituted acyclic ketones used in the syntheses of tetrasubstituted olefin-based anticancer agents are described. Lithium hexamethyldisilazide (LiHMDS)-mediated enolizations are moderately Z-selective in neat tetrahydrofuran (THF) and E-selective in 2.0 M THF/hexane. The…
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Keywords:
mediated enolization;
lithium hexamethyldisilazide;
highly substituted;
enolization highly ... See more keywords
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Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj00383b
Abstract: Two novel Zn(II)-phthalocyanines having: (i) aryl azide (3) and (ii) alkyl azide (7) functional groups at the peripheral positions have been designed/synthesized for hydrogen sulfide (H2S) sensing purposes, and their photocharacteristic properties were investigated in…
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Keywords:
tetra substituted;
detection;
aryl alkyl;
phthalocyanines tetra ... See more keywords
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Published in 2017 at "Australian Journal of Chemistry"
DOI: 10.1071/ch16364
Abstract: Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as…
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Keywords:
potential monoamine;
oxidase type;
aryl indeno;
monoamine oxidase ... See more keywords