Synthesis of Highly Substituted Azepanones from 2 H-Azirines by a Stepwise Annulation/Ring-Opening Sequence.
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DOI: 10.1021/acs.orglett.9b00999
Abstract: Bicyclic aziridines possessing a 1-azabicyclo[4.1.0]heptan-2-one core were prepared from 2 H-azirines by a stepwise annulation sequence involving a diastereoselective allylindanation, an N-acylation, and a ring-closing metathesis to construct the six-membered ring. After hydrogenation or functionalization… read more here.
Keywords: ring opening; azirines stepwise; substituted azepanones; highly substituted ... See more keywords