Synthesis of Chiral α-CF3-Substituted Benzhydryls via Cross-Coupling Reaction of Aryltitanates.
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DOI: 10.1021/acs.orglett.0c03673
Abstract: We describe a highly efficient approach toward α-CF3-substituted benzhydryls thanks to the employment of organotitanium(IV) based nucleophiles. The use of commercially available anesthetic halothane as a cheap fluorinated building block in a sequential one-pot nickel-catalyzed… read more here.
Keywords: synthesis chiral; substituted benzhydryls; coupling reaction; cf3 substituted ... See more keywords