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1
Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202102371
Abstract: Considering the special functions of fused‐ring aromatic building blocks and Si‐atom in high‐performance donor–acceptor‐conjugated materials at the same time, herein the synthesis of a novel fused‐ring tricyclic heterocycle, triisopropylsilyl‐substituted benzo[1,2‐b:4,5‐c′]dithiophene‐4,8‐dione (iBDD‐Si), an isomer of well‐known…
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Keywords:
triisopropylsilyl substituted;
benzo dithiophene;
dithiophene dione;
substituted benzo ... See more keywords
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2
Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600274
Abstract: A series of 5‐substituted benzo[d][1,3]dioxole derivatives was designed, synthesized, and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. Neurotoxicity was determined by rotarod test. In the preliminary screening, six…
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Keywords:
design synthesis;
derivatives potent;
synthesis substituted;
dioxole derivatives ... See more keywords
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1
Published in 2023 at "ChemistryOpen"
DOI: 10.1002/open.202300003
Abstract: The synthesis of three novel imidazolyl-substituted sulfur-containing heteroacenes is reported. These heteroacenes consisting of annelated benzo- and naphthothiophenes serve as precursors for the generation of open-shell quinoid heteroacenes by oxidation with alkaline ferric cyanide. Spectroscopic…
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Keywords:
shell quinoids;
benzo naphthodithiophenes;
open shell;
substituted benzo ... See more keywords
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Published in 2018 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-018-3397-x
Abstract: Considering benzimidazole as a privileged structure for developing probes of impressive pharmacological potentials, some new coumarin and pyrazole conjugates of benzimidazoles were synthesized with a sulphur linkage. Thus, 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (3) was prepared starting from simple…
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Keywords:
synthesis novel;
novel substituted;
imidazol ylthio;
various approaches ... See more keywords
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Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.02.009
Abstract: In this paper, we report the synthesis of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothiourea derivatives (4a-y) carrying active pharmacophores essential for anticonvulsant activity. The anticonvulsant activity was evaluated in vivo by maximal electroshock (MES) test and subcutaneous pentylenetetrazole…
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Keywords:
thiazol ylcarbamoyl;
methyl substituted;
benzo thiazol;
substituted phenyl ... See more keywords
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Published in 2018 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229618002176
Abstract: A concise, efficient and versatile synthesis of amino-substituted benzo[b]pyrimido[5,4-f]azepines is described: starting from a 5-allyl-4,6-dichloropyrimidine, the synthesis involves base-catalysed aminolysis followed by intramolecular Friedel-Crafts cyclization. Four new amino-substituted benzo[b]pyrimido[5,4-f]azepines are reported, and all the products…
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Keywords:
pyrimido;
benzo pyrimido;
substituted benzo;
amino substituted ... See more keywords
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Published in 2019 at "Bioinformatics and Biology Insights"
DOI: 10.1177/1177932219865533
Abstract: Plasmodium falciparum adenylosuccinate lyase (PfADSL) is an important enzyme in purine metabolism. Although several benzimidazole derivatives have been commercially developed into drugs, the template design as inhibitor against PfADSL has not been fully explored. This…
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Keywords:
benzo imidazol;
plasmodium falciparum;
imidazol methyl;
adenylosuccinate lyase ... See more keywords
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1
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27227876
Abstract: 2-Substituted benzo- and naphthothiazoles have been conveniently prepared from the intramolecular cyclization of phenylthioureas and activated thiobenzanilides or the coupling of isothiocyanates with amines under mild conditions using N-bromosuccinimide/tetrabutylammonium bromide in 1,2-dimethoxyethane (DME) under ambient…
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Keywords:
via bromosuccinimide;
naphthothiazoles via;
green approach;
approach substituted ... See more keywords