One-pot sequential synthesis of O-(halo-substituted benzyl) hydroxylammonium salts
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DOI: 10.1016/j.arabjc.2012.07.026
Abstract: Abstract In this study, we described a simple one-pot preparation of O -(halo-substituted benzyl) hydroxylamine derivatives by O -benzylation of N -hydroxyurethane, followed by basic N -deprotection. The advantages of the method were the chemo-… read more here.
Keywords: halo substituted; benzyl hydroxylammonium; one pot; hydroxylammonium salts ... See more keywords
GC–MS and GC–IR analysis of substituted N-benzyl 4-bromo-2,5-dimethoxyphenylisopropylamines
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DOI: 10.1016/j.forc.2021.100326
Abstract: Abstract The N-(methoxybenzyl- and dimethoxybenzyl)-4-bromo-2,5-dimethoxyphenylisopropylamines are a likely category of novel psychoactive substances based on a combination of structural features for the amphetamine and the NBOMe drugs. The nine compounds in this study were synthesized… read more here.
Keywords: analysis substituted; aromatic ring; benzyl bromo; substituted benzyl ... See more keywords
N2,N9-Bis(Substituted benzyl)-β-Carbolineum Bromides as Potential Anticancer Therapeutics: Design, Synthesis, Cytotoxicity, Drug-DNA Intercalation and In-Silico Binding Properties
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DOI: 10.1016/j.molstruc.2021.130771
Abstract: Abstract The present study reports a series of novel N2,N9-bis(substituted benzyl)-β-carbolineum bromides (4a-f) synthesized from L-tryptophan in three steps with excellent yields (>80%). The structures of synthesized compounds 4a-f were confirmed by 1H- and 13C-NMR,… read more here.
Keywords: dna intercalation; bis substituted; carbolineum bromides; benzyl carbolineum ... See more keywords
Characterization of the Internal Energy of Ions Produced by Electrospray Ionization Using Substituted Benzyl Ammonium Thermometer Ions.
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DOI: 10.1021/jasms.2c00116
Abstract: We propose the use of substituted benzyl ammonium species as thermometer ions to characterize the internal energy distribution of the ions produced by electrospray ionization (ESI). Crucially, we found that the activation of the benzyl… read more here.
Keywords: substituted benzyl; internal energy; benzyl ammonium; thermometer ions ... See more keywords
Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents
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DOI: 10.3390/molecules25092177
Abstract: Induction of apoptosis is a common chemotherapeutic mechanism to kill cancer cells The thiazole system has been reported over the past decades as a building block for the preparation of anticancer agents. A novel series… read more here.
Keywords: biological evaluation; anticancer agents; anticancer; synthesis biological ... See more keywords
Para-Substituted O-Benzyl Sulfohydroxamic Acid Derivatives as Redox-Triggered Nitroxyl (HNO) Sources
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DOI: 10.3390/molecules27165305
Abstract: Nitroxyl shows a unique biological profile compared to the gasotransmitters nitric oxide and hydrogen sulfide. Nitroxyl reacts with thiols as an electrophile, and this redox chemistry mediates much of its biological chemistry. This reactivity necessitates… read more here.
Keywords: redox triggered; substituted benzyl; chemistry; triggered nitroxyl ... See more keywords