Access to Enantiopure 5-, 7-, and 5,7-Substituted cis-Decahydroquinolines: Enantioselective Synthesis of (-)-Cermizine B.
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DOI: 10.1021/acs.orglett.7b00492
Abstract: Stereoconvergent cyclocondensation reactions of (R)- or (S)-phenylglycinol with appropriately substituted cyclohexanone-based δ-keto esters are the key steps of short synthetic routes to enantiopure 5-, 7-, and 5,7-substituted cis-decahydroquinolines. The factors governing the stereoselectivity of the… read more here.
Keywords: cis decahydroquinolines; access enantiopure; cermizine; substituted cis ... See more keywords
Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif.
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DOI: 10.1039/c9cc05749h
Abstract: The syntheses of substituted all-cis-1,2,3-trifluorocyclopropanes are described for the first time. The three fluorines located on each of the cyclopropyl carbons with a stereochemistry where they are all on the same face of the cyclopropane,… read more here.
Keywords: substituted cis; cyclopropanes synthesis; containing cyclopropanes; cis trifluorocyclopropanes ... See more keywords
Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway
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DOI: 10.2147/dddt.s131753
Abstract: This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis.… read more here.
Keywords: novel methoxy; apoptosis; substituted cis; methyl substituted ... See more keywords