Structural exploration of selected C6 and C7-substituted coumarin isomers as selective MAO-B inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2033643
Abstract: Abstract Monoamine Oxidase B is considered a successful target for developing antiparkinsonian drugs. Due to the side effects of current MAO-B inhibitors, there’s an urgent need for novel potent and highly selective MAO-B inhibitors. A… read more here.
Keywords: mao; substituted coumarin; mao inhibitors; coumarin isomers ... See more keywords
Computer-Aided Design and Synthesis of (Functionalized quinazoline)–(α-substituted coumarin)–arylsulfonate Conjugates against Chikungunya Virus
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147646
Abstract: Chikungunya virus (CHIKV) has repeatedly spread via the bite of an infected mosquito and affected more than 100 countries. The disease poses threats to public health and the economy in the infected locations. Many efforts… read more here.
Keywords: coumarin arylsulfonate; quinazoline substituted; substituted coumarin; chikungunya virus ... See more keywords
Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives
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DOI: 10.3390/molecules26195999
Abstract: A series of novel multi-substituted coumarin derivatives were synthesized, spectroscopically characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) inhibitory ability, their influence on cell viability in immortalized human keratinocytes (HaCaT), and cytotoxicity in… read more here.
Keywords: substituted coumarin; methyl chromen; chromen one; synthesis bioactivity ... See more keywords