Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions.
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DOI: 10.1021/acs.orglett.8b03588
Abstract: Synthesis of 1,3-substituted cyclobutyls enabled by zinc insertion into functionalized iodocyclobutyl derivatives followed by Negishi coupling with halo-heteroaromatics is reported. Two distinct sets of conditions were developed; the first involved a two-step batch protocol using… read more here.
Keywords: substituted cyclobutyls; zinc insertion; synthesis electron; negishi coupling ... See more keywords