Phosphine-Catalyzed Intramolecular Vinylogous Aldol Reaction of α-Substituted Enones.
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DOI: 10.1021/acs.orglett.1c03913
Abstract: We demonstrate the first phosphine-catalyzed intramolecular vinylogous aldol reaction (IVAR) of α-substituted enones. This strategy provides access to various pentannulated (hetero)arenes and dibenzocycloheptanones incorporated with two contiguous stereocenters, one of which is an all-carbon quaternary… read more here.
Keywords: phosphine catalyzed; intramolecular vinylogous; vinylogous aldol; aldol reaction ... See more keywords
A Radical Route to α-Substituted Enones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02783
Abstract: A versatile strategy for the α-substitution of enones through the formal fusion between enones and unactivated alkenes is described. It relies on the formation and use of α-xanthyl-β-hydroxy ketones, which can be considered as synthetic… read more here.
Keywords: route substituted; substituted enones; radical route;