Articles with "substituted estratriene" as a keyword



Photo by yapics from unsplash

2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition

Sign Up to like & get
recommendations!
Published in 2022 at "ChemMedChem"

DOI: 10.1002/cmdc.202200408

Abstract: 2‐Difluoromethoxyestratriene derivatives were designed to improve potency and in vivo stability of the drug candidate 2‐methoxyestradiol (2ME2). Compound evaluation in vitro against the proliferation of MCF‐7 and MDA MB‐231 breast cancer cells, as inhibitors of tubulin polymerisation… read more here.

Keywords: difluoromethoxy substituted; steroid sulfatase; inhibition; substituted estratriene ... See more keywords