Articles with "substituted fluorophenoxy" as a keyword



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Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors.

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Published in 2017 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2017.04.001

Abstract: In our efforts to develop novel dual c-Met/VEGFR-2 inhibitors as potential anticancer agents, a series of 2-substituted-4-(2-fluorophenoxy) pyridine derivatives bearing pyrazolone scaffold were designed and synthesized. The cell proliferation assay in vitro demonstrated that most… read more here.

Keywords: substituted fluorophenoxy; met vegfr; fluorophenoxy pyridine; dual met ... See more keywords