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Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200580
Abstract: Degradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM‐remodeling enzyme with β‐D‐endo‐glucuronidase activity overexpressed in several malignancies, and…
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Keywords:
substituted glucuronic;
hpse;
glucuronic cyclophellitols;
cyclophellitols selective ... See more keywords