New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200023
Abstract: 1‐Methyl/ethyl/benzyl‐5‐(un)substituted 1H‐indole‐2,3‐diones (2, 3, and 4) were synthesized by reaction of 5‐(un)substituted 1H‐indole‐2,3‐diones (1) with methyl iodide, ethyl chloride, and benzyl bromide. (3‐Sulfamoylphenyl)isothiocyanate (6) was obtained by the treatment of 3‐aminobenzenesulfonamide (5) with thiophosgene. Compound… read more here.
Keywords: substituted indole; thiosemicarbazones sulfamoylphenyl; new indole; dione ... See more keywords
Computational study of Ru-catalyzed cycloisomerization of 2-alkynylanilides
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DOI: 10.1007/s00894-018-3707-7
Abstract: The reaction mechanism of Ru-catalyzed cycloisomerization of 2-alkynylanilides to 3-substituted indole or 2-substituted indole was analyzed at the B3LYP level of density functional theory. The solvation effect of the system was also considered by SMD… read more here.
Keywords: computational study; reaction; substituted indole; catalyzed cycloisomerization ... See more keywords
Green and Regioselective Approach for the Synthesis of 3-Substituted Indole Based 1,2-Dihydropyridine and Azaxanthone Derivatives as a Potential Lead for SARS-CoV-2 and Delta Plus Mutant Virus: DFT and Docking Studies
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DOI: 10.1021/acsomega.2c04990
Abstract: Great attempts have been done for the development of novel antiviral compounds against SAR-CoV-2 to end this pandemic situation and save human society. Herewith, we have synthesized 3-substituted indole/2-substituted pyrrole 1,2-dihydropyridine and azaxanthone scaffolds using… read more here.
Keywords: substituted indole; dihydropyridine azaxanthone; green regioselective; delta plus ... See more keywords