Facile one-pot synthesis of 5-substituted isoxazoles and pyrazoles through microwave-promoted intramolecular cyclization of γ-hydroxyalkynal oximes and hydrazones
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic Communications"
DOI: 10.1080/00397911.2016.1263892
Abstract: ABSTRACT Simple and efficient one-pot synthesis of 5-substituted isoxazoles and pyrazoles has been developed. The formation of the target isoxazoles and pyrazoles is initiated by 1,2-nucleophilic addition of generated in situ hydroxylamine or hydrazine to… read more here.
Keywords: isoxazoles pyrazoles; intramolecular cyclization; pot synthesis; synthesis substituted ... See more keywords
Rapid Sequentially Palladium Catalyzed Four-Component Synthesis of Novel Fluorescent Biaryl-Substituted Isoxazoles
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DOI: 10.3390/catal10121412
Abstract: A series of novel 3- and 5-biaryl-substituted isoxazoles was prepared by a rapid microwave-assisted four-component three-step synthesis: concatenating Sonogashira coupling, cyclocondensation, and Suzuki coupling in a one-pot fashion. The Pd-catalyst was successfully employed in the… read more here.
Keywords: biaryl substituted; four component; rapid sequentially; substituted isoxazoles ... See more keywords