Diastereoselective hydrolysis of branched malonate diesters by Porcine Liver Esterase: Synthesis of 5‐benzyl substituted Cα‐methyl‐β‐proline and catalytic evaluation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700605
Abstract: Malonate diesters with highly branched side chains containing a preexisting chiral center were prepared from optically pure amino alcohols and subjected to asymmetric enzymatic hydrolysis by Porcine Liver Esterase (PLE). Recombinant PLE isoenzymes have been… read more here.
Keywords: methyl proline; malonate diesters; substituted methyl; hydrolysis ... See more keywords
One-pot synthesis of 3-substituted-2-[(3-methyl-1H-pyrazol-5-yl)imino]-5,6-diphenyl-1,3-thiazin-4-ones
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Sulfur Chemistry"
DOI: 10.1080/17415993.2017.1337121
Abstract: ABSTRACT New classes of 3N-substituted-2-[(3-methyl-1H-pyrazole-5-yl)-imino]-5,6-diphenyl-2H-1,3-thiazin-4(3H)-ones have been synthesized, via one pot reactions between pyrazolylthioureas, 2,3-diphenylcyclopropenone and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. The structures of the products have been confirmed by different spectroscopic analyses. A rationale for the formation of… read more here.
Keywords: imino diphenyl; substituted methyl; diphenyl thiazin; one pot ... See more keywords
Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s131753
Abstract: This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis.… read more here.
Keywords: novel methoxy; apoptosis; substituted cis; methyl substituted ... See more keywords