Novel substituted 1,8-naphthyridines: Design, synthesis, radiolabeling, and evaluation of apoptosis and topoisomerase II inhibition.
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DOI: 10.1002/ardp.202300035
Abstract: A series of seventeen 1,8-naphthyridine derivatives (5a-5q) conjugated at N1 to various substituted phenyl rings were designed and synthesized as potential topoisomerase II (Topo II) inhibitors. The antiproliferative activity of the target compounds against three… read more here.
Keywords: inhibition; apoptosis; naphthyridines design; topoisomerase ... See more keywords