Cu-Catalyzed Electrochemical Activation of Nitromethane to Access Aldoxime-Substituted Nitrile Oxide for Huisgen Reaction.
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DOI: 10.1021/acs.orglett.4c04146
Abstract: Here, we report an electrochemical approach to generate an aldoxime-substituted nitrile oxide via the activation of nitromethane. The Cu-catalyzed Huisgen reaction of this 1,3-dipole with alkynes enables successful preparation of 48 new isoxazole aldoximes, which… read more here.
Keywords: substituted nitrile; nitrile oxide; activation nitromethane; huisgen reaction ... See more keywords