7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex
Sign Up to like & getrecommendations! Published in 2023 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00607
Abstract: The development of new antimalarials is required because of the threat of resistance to current antimalarial therapies. To discover new antimalarial chemotypes, we screened the Janssen Jumpstarter library against the P. falciparum asexual parasite and… read more here.
Keywords: substituted oxadiazole; oxadiazole quinolones; activity; quinolones potent ... See more keywords
In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1900162
Abstract: Abstract The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics. To this end, a series… read more here.
Keywords: substituted oxadiazole; target; docking dynamics; dynamics studies ... See more keywords