Synthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.018
Abstract: A series of novel N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxy- lic acid derivatives were synthesized and evaluated for their biological activities. Among all synthesized target compounds, 13d exhibited the most potent antiproliferative activity against HeLa, SMMC-7721, K562 cell line (IC50 = 0.126 μM,… read more here.
Keywords: tetrahydro quinoxaline; tubulin polymerization; acid derivatives; oxo tetrahydro ... See more keywords
Synthesis, in silico ADMET, and molecular docking studies of novel 3-substituted- 5-[(4-oxo-4H-chromen-3-yl)methylene]−2-(2-phenylhydrazineylidene)thiazolidin-4-ones inducing apoptosis, autophagy, and cell cycle arrest in breast cancer cell lines
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Sulfur Chemistry"
DOI: 10.1080/17415993.2025.2536599
Abstract: A novel class of 3-Substituted-5-[(4-oxo-4H-chromen-3-yl)methylene]−2-(2-phenylhydrazineylidene)thiazolidin-4-one (3a-g and 5) was efficiently synthesized via a one-pot three components involving 1-phenyl-4-substituted-thiosemicarbazide, ethyl bromoacetate and 3-formylchromone in absolute ethanol and freshly fused sodium acetate under the effect of ultrasound… read more here.
Keywords: cell lines; cell; substituted oxo; oxo chromen ... See more keywords