Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1437-5
Abstract: Abstract15 symmetric 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides were synthesized in this work. Their structures were characterized using IR, 1H and 13C NMR, and UV–Vis spectroscopy. DFT calculations indicated that s-trans/s-trans conformation prevail in all compounds. The effects… read more here.
Keywords: phenyl ethenyl; methyl bis; ethenyl pyridinium; bis ... See more keywords
Synthesis and pharmacological screening of 4, 6-substituted di-(phenyl) pyrimidin-2-amines
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DOI: 10.1016/j.arabjc.2012.12.023
Abstract: Abstract A new series of 4, 6-substituted di-(phenyl) pyrimidin-2-amine ( IIa–d ) were synthesized by reacting chalcone derivatives with guanidine hydrochloride in the presence of dimethylformamide. The synthesized compounds were characterized by spectral analysis and… read more here.
Keywords: pharmacological screening; phenyl pyrimidin; synthesis pharmacological; substituted phenyl ... See more keywords
Synthesis of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives and evaluation of their anticancer activity
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DOI: 10.1016/j.arabjc.2013.09.008
Abstract: Abstract A novel series of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives were synthesized. In the first step salicylaldehyde was reacted with ethylacetoacetate at room temperature by stirring which gives compound (I). Compound (I) when refluxed with substituted… read more here.
Keywords: dihydro phenyl; anticancer activity; phenyl substituted; substituted phenyl ... See more keywords
Design, synthesis, anticonvulsant evaluation and docking study of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothioureas.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.02.009
Abstract: In this paper, we report the synthesis of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothiourea derivatives (4a-y) carrying active pharmacophores essential for anticonvulsant activity. The anticonvulsant activity was evaluated in vivo by maximal electroshock (MES) test and subcutaneous pentylenetetrazole… read more here.
Keywords: thiazol ylcarbamoyl; methyl substituted; benzo thiazol; substituted phenyl ... See more keywords
Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches.
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DOI: 10.1016/j.bioorg.2019.103445
Abstract: In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (2) in aqueous basic… read more here.
Keywords: piperazinyl butanamides; phenyl propenyl; phenyl; phenyl phenyl ... See more keywords
Computational studies of a series of 2-substituted phenyl-2-oxo-, 2-hydroxyl- and 2-acylloxyethylsulfonamides as potent anti-fungal agents
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DOI: 10.1016/j.heliyon.2020.e03724
Abstract: Botrytis Cinerea is a plant pathogen that affect a large number of plant species like tomatoes, Lettuce, Grapes, and Strawberries among others. Sulfonamides are widely used in pharmaceutical industries as anti-cancer, anti-inflammatory and anti-viral agents.… read more here.
Keywords: series substituted; compound; computational studies; studies series ... See more keywords
Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4'-phenyl-terpyridine compounds.
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DOI: 10.1016/j.jinorgbio.2020.111165
Abstract: A series of CdCl2 complexes (1a-1f and 2a-2c) with 4'-(substituted-phenyl)-2,2':6',2″-terpyridine compounds bearing hydrogen (L1a), p-methyl (L1b), p-phenyl (L1c), p-tolyl (L1d), p-carboxyl (L1e), p-fluoro (L1f), p-hydroxyl (L2a), m-hydroxyl (L2b) or o-hydroxyl (L2c), were prepared and characterized… read more here.
Keywords: substituted phenyl; terpyridine compounds; dna interaction; phenyl terpyridine ... See more keywords
Design, Synthesis and Bioevaluation of Substituted Phenyl Isoxazole Analogs as Herbicide Safeners.
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DOI: 10.1021/acs.jafc.0c01867
Abstract: Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted phenyl isoxazole derivatives were… read more here.
Keywords: isoxazole analogs; herbicide; phenyl isoxazole; herbicide safeners ... See more keywords
Para-Substituted α-Phenyl-N-tert-butyl Nitrones: Spin-Trapping, Redox and Neuroprotective Properties
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DOI: 10.1021/acsomega.0c03907
Abstract: In this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN) were studied. Their radical-trapping properties were evaluated by electron paramagnetic resonance, with 4-CF3-PBN being the fastest derivative to trap the hydroxymethyl radical (•CH2OH). The redox… read more here.
Keywords: para substituted; butyl nitrones; phenyl tert; tert butyl ... See more keywords
Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
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DOI: 10.1039/c8ra04987d
Abstract: In the study presented herein, 4-(1H-indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1H-indol-3-yl)butanoate (2), 4-(1H-indol-3-yl)butanohydrazide (3) and 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazole-2-thiol (4) as a nucleophile. In the second phase, various electrophiles were synthesized… read more here.
Keywords: oxadiazole scaffolds; novel indole; scaffolds substituted; substituted phenyl ... See more keywords
Copper chloride complexes with substituted 4'-phenyl-terpyridine ligands: synthesis, characterization, antiproliferative activities and DNA interactions.
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DOI: 10.1039/d0dt03989f
Abstract: Eleven copper chloride coordination compounds (1-11) with 4'-(4'-substituted-phenyl)-2,2':6',2''-terpyridine ligands bearing hydrogen (L1), cyano (L2), p-hydroxyl (L3), m-hydroxyl (L4), o-hydroxyl (L5), methoxyl (L6), iodo (L7), bromo (L8), chloro (L9), fluoro (L10) or methylsulfonyl (L11) were prepared… read more here.
Keywords: phenyl terpyridine; substituted phenyl; spectroscopy; antiproliferative activities ... See more keywords