Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides
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DOI: 10.1007/s11426-018-9393-2
Abstract: A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3′-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were… read more here.
Keywords: quinine derived; michael addition; enantioselective michael; substituted phthalides ... See more keywords