Structure-based design, synthesis, PPAR-γ activation, and molecular docking of N-substituted phthalimides
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1867-0
Abstract: N-substituted phthalimides showed peroxisome proliferator-activated receptors-γ activation in rat liver epithelial Ac2F cells in our previous study. In order to explore better peroxisome proliferator-activated receptors-γ agonists, new N-substituted phthalimide derivatives were designed and synthesized based… read more here.
Keywords: peroxisome proliferator; substituted phthalimides; proliferator activated; activated receptors ... See more keywords
Enantiomeric N-substituted phthalimides with excitatory amino acids protect zebrafish larvae against PTZ-induced seizures.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173489
Abstract: Epilepsy is a chronic neurological disease with high prevalence and adverse impacts on the quality of life of patients and caregivers. Up to one-third of individuals with epilepsy do not respond to current pharmacotherapy, underscoring… read more here.
Keywords: zebrafish larvae; amino acids; substituted phthalimides; ptz ... See more keywords