A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage
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DOI: 10.1002/cmdc.201700137
Abstract: Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo‐aging. Across the solar radiation spectrum, UV light is the main cause… read more here.
Keywords: toward development; photoprotection; substituted purines; multitarget approach ... See more keywords
1H and 13C assignments of 6‐, 8‐, 9‐ substituted purines
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DOI: 10.1002/mrc.4743
Abstract: Purines are heterocyclic aromatic organic compounds consisting of two 5‐ and 6‐membered fused rings containing nitrogen. They are present in numerous compounds, including natural products, with potent biological activity. Purine analogs are used for the… read more here.
Keywords: chemistry; substituted purines; 13c assignments; purine ... See more keywords
Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2061965
Abstract: Abstract Helicobacter pylori represents a global health threat with around 50% of the world population infected. Due to the increasing number of antibiotic-resistant strains, new strategies for eradication of H. pylori are needed. In this… read more here.
Keywords: nucleoside phosphorylase; substituted purines; interactions substituted; purine nucleoside ... See more keywords
Total synthesis of [15N]-labelled C6-substituted purines from [15N]-formamide—easy preparation of isotopically labelled cytokinins and derivatives
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DOI: 10.1098/rsos.181322
Abstract: Cytokinins (CKs) and their metabolites and derivatives are essential for cell division, plant growth regulation and development. They are typically found at minute concentrations in plant tissues containing very complicated biological matrices. Therefore, defined standards… read more here.
Keywords: synthesis 15n; substituted purines; total synthesis; 15n labelled ... See more keywords
Substituted Purines as High-Affinity Histamine H3 Receptor Ligands
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DOI: 10.3390/ph15050573
Abstract: Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives.… read more here.
Keywords: substituted purines; affinity; purines high; histamine receptor ... See more keywords