Synthesis and initial thermal behavior investigation of 2-alkenyl substituted pyrazine N-oxides
Sign Up to like & getrecommendations! Published in 2018 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2018.07.017
Abstract: Abstract The systematic syntheses of 2-alkenylpyrazine N-oxides through palladium-catalyzed C-2 selective C H olefination reaction was disclosed. Various acrylate esters substituted pyrazine N-oxides were obtained in up to 93% yields. Thermogravimetric analysis indicated that the… read more here.
Keywords: substituted pyrazine; thermal behavior; initial thermal; pyrazine oxides ... See more keywords
Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
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DOI: 10.1039/d0ra01348j
Abstract: Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among… read more here.
Keywords: substituted pyrazine; tubercular agents; piperazine homopiperazine; anti tubercular ... See more keywords