Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00813-4
Abstract: Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by activating BRAF mutations. Despite the initial success of selective BRAF inhibitors, only few patients exhibited complete responses, whereas many showed disease progression. Melanoma… read more here.
Keywords: tetra substituted; pyrrole derivatives; substituted pyrrole; p53 ... See more keywords
Total Synthesis of (±)-Rhazinilam via Red-Light-Driven Zinc(II)porphyrin-Catalyzed Radical Cyclization of N-Substituted Pyrrole.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c01681
Abstract: A red-light-driven radical cyclization strategy has been developed for the concise synthesis of (±)-rhazinilam. The transformation, catalyzed by [5,15-bis(pentafluorophenyl)-10,20-diphenylporphinato]zinc(II), enables the efficient formation of a tetrahydroindolizine core from an N-acyloxyphthalimide-substituted pyrrole, providing a key intermediate… read more here.
Keywords: substituted pyrrole; radical cyclization; synthesis rhazinilam; light driven ... See more keywords
A new route for the synthesis of multi-substituted pyrrole derivatives containing a sulfonyl scaffold via the chemistry of N-sulfonylketenimine
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Sulfur Chemistry"
DOI: 10.1080/17415993.2024.2388727
Abstract: A rapid practical new synthesis of multi-substituted pyrrole derivatives with high yields through a novel four-component reaction of sulfonyl azides, terminal alkynes, nitro compounds, and trichloroacetonitril is a remarkable achievement in organic chemistry. This strategy… read more here.
Keywords: chemistry; substituted pyrrole; synthesis; multi substituted ... See more keywords