Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells
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DOI: 10.1007/s10637-019-00813-4
Abstract: Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by activating BRAF mutations. Despite the initial success of selective BRAF inhibitors, only few patients exhibited complete responses, whereas many showed disease progression. Melanoma… read more here.
Keywords: tetra substituted; pyrrole derivatives; substituted pyrrole; p53 ... See more keywords