Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles.
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DOI: 10.1016/j.tet.2018.04.017
Abstract: Highly functionalized pyrroles with appropriate regiochemical functionality represent an important class of marine natural products and potential drug candidates. We describe herein a detailed study of the reaction of α-aminoacid esters with vinylogous amides and… read more here.
Keywords: amides halovinylaldehydes; regiospecific synthesis; substituted pyrroles; vinylogous amides ... See more keywords
One-pot synthesis of N-substituted pyrroles from nitro compounds and 2,5-hexadione over a heterogeneous cobalt catalyst
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DOI: 10.1039/c7nj01898c
Abstract: In this study, the one-pot heterocyclization of nitro compounds with 2,5-hexadione was studied for the synthesis of N-substituted pyrroles via a Paal–Knorr condensation process. The heterogeneous cobalt–nitrogen catalyst (Co–Nx/C-800-AT) was found to be active for… read more here.
Keywords: substituted pyrroles; synthesis substituted; one pot; nitro compounds ... See more keywords
Novel One-Pot Cyclization of the Blaise Reaction Intermediate and Arylglyoxals: The Synthesis of Substituted NH-Pyrroles
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DOI: 10.1055/s-0036-1588168
Abstract: A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively to afford a wide variety… read more here.
Keywords: blaise reaction; substituted pyrroles; reaction intermediate; synthesis substituted ... See more keywords