Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00802
Abstract: Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99%… read more here.
Keywords: pharmaceutically relevant; aryl substituted; substituted pyrrolidines; imine reductases ... See more keywords
Selective Golgi α-mannosidase II inhibitors: N-alkyl substituted pyrrolidines with a basic functional group
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d1nj01176f
Abstract: Enzymatic assays, molecular modeling and NMR studies of novel 1,4-dideoxy-1,4-imino-l-lyxitols provided new information on the GH38 family enzyme inhibitors and their selectivity. read more here.
Keywords: golgi mannosidase; mannosidase inhibitors; alkyl substituted; inhibitors alkyl ... See more keywords