Synthesis of chalcones from 3-formyl-substituted pyrrolo[3,4-f]indole-5,7-diones
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DOI: 10.1007/s11172-017-1823-7
Abstract: General methods to access new 3-formyl-substituted 1-methoxypyrrolo[3,4-f]indole-5,7-diones were developed. The synthesized 3-formylindoles react with heterocyclic aceto-phenones under acid-catalyzed conditions to give different chalcones. read more here.
Keywords: substituted pyrrolo; chalcones formyl; pyrrolo indole; indole diones ... See more keywords
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00408
Abstract: Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo[2,3- d]pyrimidine analogues 7-12 were synthesized and tested for selective cellular uptake by folate receptors (FRs) α and β or the proton-coupled folate transporter (PCFT) and for antitumor efficacy. Compounds 8, 9,… read more here.
Keywords: substituted pyrrolo; pyrimidine analogues; folate; pyrrolo pyrimidine ... See more keywords
Abstract 789: Multi-targeted novel 5-substituted pyrrolo[3,2-d]pyrimidines with tumor-selective targeting and inhibition of cytosolic de novo purine biosynthesis and mitochondrial one-carbon metabolism
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DOI: 10.1158/1538-7445.sabcs18-789
Abstract: One-carbon (C1) metabolism supports a number of physiological and pathophysiological processes ranging from stem cell renewal to cancer progression. Clinically used antifolates are transported into both tumor and normal cells by the ubiquitously expressed reduced… read more here.
Keywords: substituted pyrrolo; pyrrolo pyrimidines; metabolism; carbon ... See more keywords
Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics
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DOI: 10.3390/molecules24142656
Abstract: Pyrrolo[3,2-d]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has been on modifications to the pyrimidine ring, with enzymatic recognition often modulated by… read more here.
Keywords: substituted pyrrolo; structural biological; investigations series; biological investigations ... See more keywords