Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors
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DOI: 10.3390/molecules30122641
Abstract: 6-Aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines have promising properties as colony-stimulating factor 1 receptor (CSF1R) inhibitors. Inspired by these antagonists, two series of 1,2,3-triazole analogues (28 compounds) were synthesized and evaluated as CSF1R inhibitors. Enzymatic IC50 profiling showed that 27… read more here.
Keywords: triazole substituted; pyrrolopyrimidines csf1r; substituted pyrrolopyrimidines; evaluating triazole ... See more keywords