Synthesis of N-Unsubstituted and N3-Substituted Quinazoline-2,4(1H,3H)-diones from o-Aminobenzamides and CO2 at Atmospheric Pressure and Room Temperature.
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DOI: 10.1021/acs.orglett.3c00614
Abstract: The unprecedented metal-free synthesis of both N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones from o-aminobenzamides and CO2 under atmospheric pressure at room temperature is developed. This protocol easily allows for variations of functional groups (including alkyl, aryl, and… read more here.
Keywords: substituted quinazoline; unsubstituted substituted; synthesis unsubstituted; diones aminobenzamides ... See more keywords
Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2189578
Abstract: Abstract The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In this study, we designed 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual… read more here.
Keywords: substituted quinazoline; dione derivatives; quinazoline dione; dual met ... See more keywords