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   Articles with "substituted quinolines" as a keyword



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Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors

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recommendations! Published in 2019 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.201900101

Abstract: Based on the cabozantinib scaffold, novel c‐Met inhibitors were rationalized from the limited knowledge of structure‐activity relationships for the quinoline 6‐position. Emphasis was given to modifications capable of engaging in additional polar interactions with the… read more here.

Keywords: design synthesis; biological evaluation; met inhibitors; substituted quinolines ... See more keywords
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Spotlight on 4‐substituted quinolines as potential anti‐infective agents: Journey beyond chloroquine

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recommendations! Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200361

Abstract: Continued emerging resistance of pathogens against the clinically approved candidates and their associated limitations continuously demand newer agents having better potency with a more suited safety profile. Quinoline nuclei containing scaffolds of natural and synthetic… read more here.

Keywords: infective agents; anti infective; substituted quinolines; quinolines potential ... See more keywords
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Nickel‐Catalyzed Sequential Dehydrogenation and Cyclization of 2‐Amino(Nitro)‐benzyl Alcohols with Alkyl Alcohols: Synthesis of C‐3‐Substituted Quinolines

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recommendations! Published in 2023 at "ChemCatChem"

DOI: 10.1002/cctc.202300412

Abstract: We herein reported a general and efficient Ni‐catalyzed protocol for sequential double de‐hydrogenative cyclization of 2‐amino(nitro)‐benzyl alcohols with primary alcohols to C‐3‐substituted quinolines releasing water and dihydrogen as by products. As a special highlight, late… read more here.

Keywords: amino nitro; benzyl alcohols; nitro benzyl; cyclization amino ... See more keywords
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Copper-Catalyzed Cyclization of 2-Alkynylanilines to Give 2-Haloalkoxy-3-alkyl(aryl)quinolines.

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recommendations! Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.2c04314

Abstract: Herein we describe a method to produce 2-haloalkoxy-3-substituted quinolines via the cyclization of 2-alkynylanilines with TMSCF3 and THF. This synthetic method uses inexpensive and easy-to-handle TMSCF3 and employs a commercially available CuI catalyst to transform… read more here.

Keywords: catalyzed cyclization; alkynylanilines give; cyclization; cyclization alkynylanilines ... See more keywords
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Substituent effects on the crystallization mechanisms of 7-chloro-4-substituted-quinolines

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recommendations! Published in 2020 at "CrystEngComm"

DOI: 10.1039/d0ce00214c

Abstract: The crystallization mechanisms of a series of fourteen 7-chloro-4-substituted-quinolines (substituents: (1) OCH3, (2) OCH2CH3, (3) OCH2CHCH2, (4) O(CH2)2OH, (5) O(CH2)3OH, (6) NH(CH2)2CH3, (7) NH(CH2)3CH3, (8) NH(CH2)2OH, (9) NHCH(CH2CH3)CH2OH, (10) NH(CH2)2Cl, (11) NHNCH(C6H5), (12) NHNCH(2-FC6H4), (13)… read more here.

Keywords: chloro substituted; ch2; crystallization; substituted quinolines ... See more keywords
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Boron-Catalyzed Hydrogenative Reduction of Substituted Quinolines to Tetrahydroquinolines with Hydrosilanes

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recommendations! Published in 2017 at "Synlett"

DOI: 10.1055/s-0036-1588442

Abstract: A metal-free procedure for the hydrogenative reduction of substituted N-heteroaromatics has been developed by using hydrosilanes as reducing agents. The optimized conditions were successfully applied to the reactions of quinolines, quinoxalines, and quinoline N-oxides. They… read more here.

Keywords: reduction; reduction substituted; substituted quinolines; boron catalyzed ... See more keywords

Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14071466

Abstract: Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering… read more here.

Keywords: hiv integrase; bromo; substituted quinolines; multi substituted ... See more keywords