Stereoselective Syntheses of ( E)-γ',δ-Bisboryl-Substituted syn-Homoallylic Alcohols via Chemoselective Aldehyde Allylboration.
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DOI: 10.1021/acs.orglett.9b00461
Abstract: The development of a novel ( Z)-α,δ-bisboryl-substituted crotylboron reagent is reported. Ni-catalyzed 1,4-diboration of dienylboronate provided the targeted crotylboronate in good yield with high regio- and stereoselectivity. Chemo- and stereoselective addition of this crotylboron reagent… read more here.
Keywords: syntheses bisboryl; substituted syn; syn homoallylic; bisboryl substituted ... See more keywords
Hydrogen-Bonding Ability of Noyori–Ikariya Catalysts Enables Stereoselective Access to CF3-Substituted syn-1,2-Diols via Dynamic Kinetic Resolution
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DOI: 10.1021/acscatal.3c00980
Abstract: Stereopure CF3-substituted syn-1,2-diols were prepared via the reductive dynamic kinetic resolution of the corresponding racemic α-hydroxyketones in HCO2H/Et3N. (Het)aryl, benzyl, vinyl, and alkyl ketones are tolerated, delivering products with ≥95% ee and ≥87:13 syn/anti. This… read more here.
Keywords: noyori ikariya; cf3 substituted; substituted syn; dynamic kinetic ... See more keywords