Diastereoselective synthesis of highly substituted tetrahydroquinolines using benzoylacetonitrile via aza Diels–Alder reaction
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153063
Abstract: Abstract Diastereoselective aza-Diels–Alder reaction between in situ generated 2-aminophenyl-substituted enones and α-cyano-α,β-unsaturated aromatic ketone has been developed. In the presence of TEA as a catalyst prepared highly substituted tetrahydroquinolines with an all-carbon quaternary center in… read more here.
Keywords: aza diels; alder reaction; highly substituted; diels alder ... See more keywords
HFIP-Empowered One-Pot Synthesis of C4-Aryl-Substituted Tetrahydroquinolines with Propargylic Chlorides and Anilines.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04299
Abstract: Transition-metal-free, practical one-pot synthesis of C4-aryl-substituted tetrahydroquinolines from simple anilines and readily accessible propargylic chlorides has been developed. Activation of the C-Cl bond by 1,1,1,3,3,3-hexafluoroisopropanol turned out to be the key interaction, which allowed C-N… read more here.
Keywords: propargylic chlorides; one pot; pot synthesis; synthesis aryl ... See more keywords