Chemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10094-2
Abstract: HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clinical settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were… read more here.
Keywords: virus type; chemistry; ic50; substituted triazole ... See more keywords
Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113039
Abstract: Building on our previous work that discovered 1,2,4-triazole-spirodienone as a promising pharmacophore for anticancer activity, we have further diversified 1,2,4-triazole- spirodienone derivatives and synthesized a series of novel naphthalene-substituted triazole spirodienones to explore their antineoplastic… read more here.
Keywords: naphthalene substituted; anticancer activity; substituted triazole; anticancer ... See more keywords
Copper(II)-Catalyzed C-H Nitrogenation/Annulation Cascade of Ketene N,S-Acetals with Aryldiazonium Salts: A Direct Access to N2-Substituted Triazole and Triazine Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04335
Abstract: Direct synthesis of N2-substituted triazole and triazine derivatives has been a challenge in N-heterocyclic chemistry. Under copper(II) catalysis ketene N,S-acetals, that is, alkylthio-substituted enaminones, efficiently reacted with aryldiazonium salts to allow the regioselective generation of… read more here.
Keywords: aryldiazonium salts; triazole triazine; substituted triazole; triazine derivatives ... See more keywords
Metal-free 1,3-dipolar cyclization of azides with HFO-1233zd(E) under amine participation: one-step regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00333g
Abstract: A simple and metal-free strategy for regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd (E) and amines in aqueous reaction medium. The defluorination functionalization of the... read more here.
Keywords: triazole carboxamide; substituted triazole; metal free; synthesis substituted ... See more keywords