7‐Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000454
Abstract: This study explores the potential of 7‐amidocoumarins as multitarget agents against Parkinson's and Alzheimer's diseases, by modulating the substitution patterns within the scaffold. Sixteen compounds were synthesized via 7‐amino‐4‐methylcoumarin acylation, and in vitro evaluation of the… read more here.
Keywords: substitution pattern; amidocoumarins multitarget; multitarget agents; substitution ... See more keywords
Changing up BN-Polystyrene: Effect of Substitution Pattern on the Free-Radical Polymerization and Polymer Properties
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DOI: 10.1021/acs.macromol.9b00466
Abstract: Azaborinine-substituted polymers are poised to dramatically expand the diversity and functionality of polystyrenes via BN for CC substitution, but this new class of materials remains underexplored. Although formally isosteric to the respective all-carbon polystyrene derivatives,… read more here.
Keywords: free radical; substitution pattern; radical polymerization; polymer properties ... See more keywords
Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031096
Abstract: Salt bridge (SB, double-charge-assisted hydrogen bonds) formation is one of the strongest molecular non-covalent interactions in biological systems, including ligand–receptor complexes. In the case of G-protein-coupled receptors, such an interaction is formed by the conserved… read more here.
Keywords: substitution pattern; pattern basic; geometry; pyrrolo quinoline ... See more keywords