Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation
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DOI: 10.3389/fimmu.2017.00537
Abstract: Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of… read more here.
Keywords: substitution profiles; amino acid; gene specific; substitution ... See more keywords