Exploring Mechanisms of Biotic Chlorinated Alkane Reduction: Evidence of Nucleophilic Substitution (SN2) with Vitamin B12.
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DOI: 10.1021/acs.est.1c06066
Abstract: Chlorinated alkanes are notorious groundwater contaminants. Their natural reductive dechlorination by microorganisms involves reductive dehalogenases (RDases) containing cobamide as a cofactor. However, underlying mechanisms of reductive dehalogenation have remained uncertain. Here, observed products, radical trap… read more here.
Keywords: cobalamin; sn2; nucleophilic substitution; substitution sn2 ... See more keywords