A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand
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DOI: 10.1093/nar/gkac779
Abstract: Abstract The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since… read more here.
Keywords: mitochondria specific; heavy strand; substitutions heavy; generation ... See more keywords