Substitutions in PBP3 confer resistance to both ampicillin and extended‐spectrum cephalosporins in Haemophilus parainfluenzae as revealed by site‐directed mutagenesis and gene recombinants
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DOI: 10.1093/jac/dkx157
Abstract: Objectives: To determine the association of amino acid substitutions in PBP3 with &bgr;‐lactam susceptibility in Haemophilus parainfluenzae. Methods: Single and multiple amino acid mutations at positions 385, 511 and 526 were introduced into PBP3 of… read more here.
Keywords: directed mutagenesis; resistance ampicillin; resistance; substitutions pbp3 ... See more keywords