Substrate access path-guided engineering of L-threonine aldolase for improving diastereoselectivity.
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DOI: 10.1039/d2cc02644a
Abstract: The L-threonine aldolase from Leishmania major was engineered to improve its diastereoselectivity by a CAST/ISM strategy, providing insights into the relationship between the physico-chemical properties of the substrate access path and diastereoselectivity. The steric hindrance,… read more here.
Keywords: access path; substrate access; diastereoselectivity; threonine aldolase ... See more keywords