Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
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DOI: 10.1038/s41589-021-00783-w
Abstract: CUB domain-containing protein 1 (CDCP1) is an oncogenic orphan transmembrane receptor and a promising target for the detection and treatment of cancer. Extracellular proteolysis of CDCP1 by poorly defined mechanisms induces pro-metastatic signaling. We describe… read more here.
Keywords: cdcp1; substrate biased; activity based; biased activity ... See more keywords